Ambroxol - Wikipedia, The Free Encyclopedia 1h21i

6/4/13

Ambroxol - Wikipedia, the free encyclopedia

Ambroxol From Wikipedia, the free encyclopedia

Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Mucobrox, Lasolvan, Mucoangin, Surbronc and Lysopain. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract, which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactant acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.[1][2] Ambroxol is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply".[3] There are many different formulations developed since the first marketing authorisation in 1978. Ambroxol is available as syrup, tablets, pastilles, dry powder sachets, inhalation solution, drops and ampules as well as effervescent tablets. Ambroxol also provides pain relief in acute sore throat. Pain in sore Ambroxol throat is the hallmark of acute hydrochloride pharyngitis.[4] Sore throat is tablets in Japan usually caused by a viral infection. The infection is self limited and the patient recovers normally after a few days. What is most bothering for the patient is the continuous pain in the throat maximized when the patient is swallowing. The main goal of treatment is thus to reduce pain. The main property of Ambroxol for treating sore throat is the local anaesthetic effect, described first in the late 1970s,[5][6] but explained and confirmed in more recent work.

Ambroxol

Systematic (IUPAC) name trans-4-(2-Amino-3,5-dibrombenzylamino)-cyclohexanol

Clinical data AHFS/Drugs.com

International Drug Names

Pregnancy cat.

?

Legal status

? Identifiers

CAS number

18683-91-5

ATC code

R05CB06

PubChem

CID 2132

ChemSpider

10276826

UNII

200168S0CL

KEGG

D07442

ChEMBL

CHEMBL153479 Chemical data

Formula

C13H18Br2N2O

Mol. mass

378.10

SMILES InChI (what is this?) ()

Ambroxol is a very potent inhibitor of the neuronal Na+ channels.[7] This property led to the development of a 1/2

en.wikipedia.org/wiki/Ambroxol

6/4/13

Ambroxol - Wikipedia, the free encyclopedia

Ambroxol is a very potent inhibitor of the neuronal Na+ channels.[7] This property led to the development of a lozenge containing 20 mg of ambroxol. Many state-of-the-art clinical studies[4] have demonstrated the efficacy of Ambroxol in relieving pain in acute sore throat, with a fast onset of action and a long duration of effect of at least 3 hours. Additional anti-inflammatory properties of Ambroxol are of clinical relevance since treatment lead to a marked reduction of redness of the patient’s sore throat.

References 1. ^ Sanderson RJ et al. (1976), "Morphological and physical basis for lung surfactant action.", Respir Phys 27 (3): 379–92, PMID 989610 (//www.ncbi.nlm.nih.gov/pubmed/989610) 2. ^ Kido H et al. (Nov 2004), "Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential.", Biol Chem 385 (11): 1029–034, PMID 15576322 (//www.ncbi.nlm.nih.gov/pubmed/15576322) 3. ^ Malerba M, Ragnoli B. (Aug 2008), "Ambroxol in the 21st century: pharmacological and clinical update.", Expert Opin Drug Metab Toxicol. 4 (8): 1119–29, doi:10.1517/17425255.4.8.1119 (http://dx.doi.org/10.1517%2F17425255.4.8.1119), PMID 18680446 (//www.ncbi.nlm.nih.gov/pubmed/18680446) 4. ^ a b de Mey C. et al. (2008), "Efficacy and safety of ambroxol lozenges in the treatment of acute uncomplicated sore throat.", Arzneimittelforschung 58 (11): 557–68, doi:10.1055/s-0031-1296557 (http://dx.doi.org/10.1055%2Fs-0031-1296557), PMID 19137906 (//www.ncbi.nlm.nih.gov/pubmed/19137906) 5. ^ Püschmann S, Engelhorn R. (1978), "Pharmakologische Untersuchungen des Bromhexin-Metaboliten Ambroxol. (Pharmacological study on the bromhexine-metabolite ambroxol)", Arzneimittelforschung 28 (5a): 889–98, PMID 581987 (//www.ncbi.nlm.nih.gov/pubmed/581987) 6. ^ Klier KF, Papendick U. (1977), "Die lokalanaesthetische Wirkung von NA-872-haltigen Augentropfen. (The local anesthetic effect of NA872-containing eyedrops)", Med Monatsschr. 31 (12): 575–8, PMID 593223 (//www.ncbi.nlm.nih.gov/pubmed/593223) 7. ^ Weiser T. (2006), "Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.", Neurosci Lett. 395 (3): 179–184, doi:10.1016/j.neulet.2005.10.058 (http://dx.doi.org/10.1016%2Fj.neulet.2005.10.058), PMID 16293367 (//www.ncbi.nlm.nih.gov/pubmed/16293367)

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en.wikipedia.org/wiki/Ambroxol

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