UNIVERSIDAD DE ZAMBOANGA School of Allied Medicine (SAM)
Pharmacy Department Course Syllabus and Topic Outline Chemistry and Pharmacy of Organic Medicinals SY: 2016-2017 Second Semester Course Title
:
Chemistry and Pharmacy of Organic Medicinals
Course no.
:
Pharmaceutical Chemistry 2
Credits Units :
5 units credit (3 units lecture, 2 units laboratory
Placement
3rd Year BS Pharmacy, Second Semester
:
Hours :
3 hours lecture and 6 hours laboratory / week
Course Description: This course covers the Chemistry and Pharmacy of Organic Medicinals, with emphasis on those official in the USP and NF and other Standard Compendia. This is the study the Structure Activity Relationships of Organic Medicinals: including their physicochemical properties in relation to their biological activity, preparation and/or synthesis, uses and doses. SUGGESTED TEACHING APPROACH: The study of Pharmaceutical Chemistry should include: • An introduction to the general properties and functions of drugs; • A general idea of how drugs are designed, developed, and tested; • The use of structural modification, asymmetric synthesis to get the desired optical isomer; • The drug testings made before drugs are introduced to the public; • An awareness of the contribution that science continues to make towards maintaining the health and well-being of the world’s population. Prerequisites : Pharm. Chemistry 1 (Inorganic Medicinal & Pharmaceutical Chemistry) Pharmaceutical Biochemistry General Objectives: The objectives of the syllabus are to provide students who have exceptional ability and interest in Chemistry the opportunity to: (a) Apply the principles of chemistry for an understanding of drug action and design (b) Understand and apply various analytical techniques to chemical analysis (c) Be enthused to engage in research and rationalize ethical issues
At the end of the course, the students should be able to: 1. Apply the knowledge, skills, and principles of organic chemistry to medicinal and pharmaceutical chemistry. 2. Learn the Uses, synonyms and other information regarding Organic Medicinal of Pharmaceutical Importance. 3. Discuss the official Organic substances used as therapeutic and diagnostic agents. 4. Manifest an appreciation of the pharmacist’s social and professional responsibilities in maintaining or restoring the health of men and animals. 5. Understand the High Moral and Ethical Standards of the Pharmacy Profession. LEARNING STRATEGIES: Some possible Modes for Learning could include: For Lecture Module: • Lectures, possibly including Guest Lectures from Industry and Research • Literature Review of Medicinal Agents • Power Points Presentations • Case Studies / Analyses
For Laboratory Module: Laboratory Exercises (Synthesis) Visits to Laboratories & Industries (Optional) Group & Individual Seat Work Research Experimental Explorations
While practical work is not a requirement for this course, students would stand to benefit from learning experiences which complement the study of Pharmaceutical Chemistry. These include experiences which facilitate the development of skills or enhance familiarity with the processes associated with drug design and synthesis, and also hands-on experiences for the various spectroscopic, separation and purification techniques.
SYLLABUS DESIGN: The syllabus is supposedly based on a 54 lectures hours of teaching and self-directed independent learning out of Curriculum Time. But the allotted time for the complete discussion of the topics required per term will be about 65 hours, which will be gotten from the laboratory hours and or make Up Classes (to be scheduled). The subject is pitched at undergraduate Junior Year of BS Pharmacy Curriculum. The students are expected to perform and comply the following commitments & responsibilities: 1. 2. 3. 4. 5. 6.
Attend the class regularly. Ten absences without valid reasons will be considered dropped. Submit requirements on time. Participate actively in class discussion. Observe the SAM House Rules, Department Policies and Implied Conduct of the Course. Take the Examinations and Quizzes on time, following strictly – NO PERMIT, NO EXAM POLICY. Develop core values of the Universidad de Zamboanga such as Honesty, Integrity, Morality, Confidentiality, and Trustworthiness.
Vision, Mission and Objectives of UZ, School of Allied Medicine and Department of Pharmacy. GRADING SYSTEM: For LECTURE: MAJOR EXAMS
For LAB: %
ITEMS
TIME(Hr )
Frequency:
60%
Nlt 150
1.5 – 2.0
4 exams
(PM/MT/PF/Final )
QUIZZES TOTAL:
40% 100 %
Nlt 20
1 Q/Ch
3-5 / term
%
ITEMS
TIME(Hr
Frequency
MAJOR EXAMS
60%
NLT100
1.0-1.5
4 exams
QUIZZES/EXPT s
40% Eq. 30s
3Days
3 Expt / term
(AT/P/GWO/Pr) (RUBRIC Based)
100%
COURSE OUTLINE
Time Allotted
PREMID Coverage
15 hours
Chapter 1:
INTRODUCTION
1 hour
Chapter 2:
Drug Design Strategies
2 hours
Chapter 2.5 Drug Product Development Chapter 3:
(Optional)
2 hour 2 hours
Chapter 4:
Metabolic Changes of Drugs and Related Organic Compounds Biotechnology & Drug Discovery
Chapter 5:
IMMUNOBIOLOGICALS
2 hours
Chapter 6:
Anti-Infective Agents
4 hours
MIDTERM Coverage Chapter 7:
2 hours
15 hours ANTIMALARIALS
2 hours
Chapter 8:
Antibacterial Antibiotics
4 hours
Chapter 9:
Antiviral Agents
2 hours
Chapter 10: Antineoplastic Agents
2 hours
Chapter 11: Agents for Diagnostic Imaging
2 hours
Chapter 12: Central Nervous System Depressants
3 hours
PREFINAL Coverage
15 hours
Chapter 13: Dopaminergic Signaling Agents
2 hours
Chapter 14:
2 hours
ANTICONVULSANTS
Chapter 15: Central Nervous System Stimulants
2 hours
Chapter 16: Adrenergic Agents
2 hours
Chapter 17:
2 hours
Cholinergic Drugs & Related Compounds
Chapter 18: Drugs acting on the Renal System
1 hour
Chapter 19: Cardiovascular Agents
4 hours
FINAL Coverage
20 hours
Chapter 20: Hormone-Related Disorders: Non-Steroidal Therapies 2 hours Chapter 21: Agents Treating Bone Disorders
2 hour
Chapter 22:
2 hour
ANESTHETICS
Chapter 23: Histamine and Antihistaminic Agents
2 hours
Chapter 24:
2 hours
ANALGESICS
Chapter 25: Steroid Hormones and Therapeutically Related Compounds Chapter 26: Prostaglandins, Leukotrienes and Essential and Fatty Acids Chapter 27: Proteins, Enzymes & Peptide Hormones
2 hours
Chapter 28:
2 hour
VITAMINS
Chapter 29: An Introduction to the Medicinal Chemistry of Herbs Laboratory
LaboratoryEquipment: REFERENCES: (Old Sources)
:
2 hours 2 hours
2 hours
Synthesis of simple molecules – changes in structure Biological activity testing Toxicity testing Standard Chemistry Laboratory Equipment Burger, Alfred, etal, (1995) Vol.I, Principles and Practice [in Burger’s Medicinal Chemistry and Drug Discovery, Manfred E. Wolff, ed.], New York, John Wiley and Sons, Inc., xi, 1064 p. Burger, Alfred, (1970). Medicinal Chemistry, 3rd edition. New York, WileyInterscience, xix, 1712, 4183 p. Burley, Denis, Joan Clarke and Louis Lasagna,(1993). Pharmaceutical Medicine, 2nd ed., London, Edward Arnold, 361 p. Doerge, Robert (Ed.), (1982). Wilson and Gisvolds’ Textbook of Organic Medicinal and Pharmaceutical Chemistry, 8th ed., Philadelphia, Lippincott Co., Foye, William O. (1989). Principles of Medicinal Chemistry, 3rd edition, Philadelphia, Lea and Febiger, 925 p. Kennewell, Peter and John Taylor, (1993). Modern Medicinal Chemistry. New York, Ellis Hornwood, 290 p. Roberts, Stanley and Barry Price, (1985). Medicinal Chemistry: The Role of Organic Chemistry in Drug Research, London, academic Press, xix, 296 p. Wolff, Manfred E. and Alfred Burger, (1995). Burger’s Medicinal Chemistry and Drug Discovery, 5th ed., New York, Wiley and Sons, 1354 p. Gennaro, Alfonso R. (Ed.), (2000). Remington’s Pharmaceutical Sciences,
20th ed., Pennsylvania, Mack Publishing Company, xvi, 2000 p.
Main Reference:
Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds’ Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed., 2011, Philadelphia, Lippincott Co. Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2 . 2nd Edition. Reed Elsevier India Private Limited. New Delhi, India.
Additional References: Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2 (New Books) 2nd Edition. Reed Elsevier India Private Limited. New Delhi, India. Allen, Jr. Lloyd V., et al. (2013) Remington: The Science and Practice of Pharmacy 22nd Edition. University of the Sciences in Philadelphia. Pharmaceutical Press. Michigan, USA. Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co. Philadelphia, USA Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds’ Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed., 2011, Philadelphia, Lippincott Co. USA Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy. 21st Edition. University of the Sciences in Philadelphia. Lippincott Williams & Wilkins, Baltimore, Maryland, USA. 361-384 p. Ch-24 E-Book References :
Seager, Spencer L.; Slabaugh, Michael R. (2014). Chemistry for Today: General, Organic and Biochemistry. 8th Edition.Brooks/Cole, Cengage Learning Belmont, CA USA Atkins, Peter; Jones, Loretta; Laverman, Leroy. (2013). Chemical Principles. The Quest For Insight. 6th Edition. W. H. Freeman and Company. New York, USA. Allen, Jr. Lloyd V. (editor) (2013). Remington: An Introduction to Pharmacy. Royal Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London, UK. Felton, Linda A. (editor). (2013). Remington: Essentials of Pharmaceutics. 1st Edition. Royal Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London, UK Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co. Philadelphia, USA. Cairns, Donald. (2012). Essentials of Pharmaceutical Chemistry. 4th Edition. Pharmaceutical Press: Royal Pharmaceutical Society of Great Britain, UK. Alagarsamy, V. (2010). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2 1st Edition. Reed Elsevier India Private Limited. New Delhi, India. Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy 21st Edition.University of the Sciences in Philadelphia. Lippincott Williams & Wilkins, Baltimore, Maryland, USA. 361-384 p. Ch-24
Pharmacy Reviewers: ACE Learning Specialist Review Lecture Compilation. June 2015. BREX Pharmacy Review Program for Local Pharmacy and Foreign Pharmacy 2013 Edition. March 2014 BREX Pharmacy Review Program for Local Pharmacy and Foreign Pharmacy 2011 Edition. March 2012 PACOP Comprehensive Pharmacy Reviewer 2012 Edition. June 2012 University of the Philippines (UP) – Manila Comprehensive Pharmacy Reviewer January 2012 Edition. March 2012 San Carlos University Comprehensive Pharmacy Reviewer March 2011 INRESS Review Center Comprehensive Pharmacy Reviewer May 1998. South Western University Pharmaceutical Chemistry Review Notes, March 1998. Enhanced by:
Reviewed by:
BEN-FRAZIER U. SABTULA, RPh, MSPharm (CAR) Instructor
MARY BELEN T. MOGOL, RPh. MS Pharm, Ph.D Program Head – Pharmacy Department
Noted by:
Approved by:
MADELYN F. CANDIDO, MLS, Ph.D Chief Librarian
NENITA SJ. EUSTAQUIO, RMT, MSMT DEAN – School of Allied Medicine Adapted from:
Philippine Association of Colleges of Pharmacy (PACOP) Revision #-07. November, 2016