Generic Name: Amikacin Sulfate 17p5n

Drug Name

Action

Generic Name:

Inhibits protein synthesis by binding directly to the 30S ribosomal sub unit; bactericidal

amikacin sulfate

Indication •

Brand Name: Amikin

* Route: IV

Classification: Amino glycoside

Available forms: *Infection: pediatric:50m g/ml,250 mg/ml

Onset: immediate

•

Peak: 30mins. Duration: 8-12 hrs. * Route: I.M

•

Onset: unknown Peak: 1hr.

NSS: 5mg/ml(500m

Duration: 812hrs.

•

Serious infection cause by sensitive restrains of Pseudom onas aeruginus a, E.coli, Proteus, Klebsiella, staphyloc occus Uncompli cated UTI caused by organism susceptibl e to less toxic drugs. Active tuberculo sis, with other antituber culotics Mycobact erium

Contraindicati on •

•

Contrain dicated in patients hypersen sitive to drug or other aminogy cosides. Use cautiousl y in patients with impaired renal function or neuromu scular disorders , in neonates and infants and in elderly patients.

Adverse Effect CNS: neuromu scular blockade

Nursing Considerations •

•

EENT: ototoxicit y

•

• •

•

•

Obtain specimen for culture and sensitivity test before giving first dose. Therapy may begin while awaiting the results. Evaluate patient’s hearing before and during therapy if he will be receiving drug for longer than 2 weeks. Notify prescriber if patient has tinnitus, vertigo, or hearing loss. Weigh patient and review renal function studies before therapy begins. Correct dehydration before therapy because of increase risk of toxicity. Obtain blood for peak level 1 hour I.M injection and 30 mins. to 1 hour after IV infusion ends; for trough levels draw blood just before the next dose. Don’t collect blood in a heparinized tube; heparin is incompatible with aminoglycosides. Peak drug levels more than 35 mcg/ml and trough levels more than 10 mcg/ml may linked to a higher risk of toxicity Watch for signs and symptoms of super infection (especially URT), such as continued fever, chills, and increased pulse rate.