Patofisiologi Bph 2n715i

Patofisiologi BPH Aging

Expression of antiapototic gene gene >>

Regulatory TGF-β <<

Inhibitor proliferation <<

BCL 2

Proliferatio n >>

Hyperplasia Produce & secrete GF (HB-EEGF, bFGR/FGR2) Testostero GF ECM ne (extracellular matrix)>> Promotes adhesion, migration, proliferation epithel and stromal cells Expression CRY 61 >> (an early immediate respon gene)

Enzyme 5α

DHT

Reseptor (AR)

Hormone complex receptor Affect normal cell morphology Imbalance proliferation and cell death

Tranformation nuclear Masuk receptor nuklesu dan melekat dgn kromatin

Expression VEGF Capable of secreting Trankripsi Sintesis Inflammation Hyperpla BPH Pertumbuhan (potent epithelial potent epithelial mRNA>> Activated T andprotein sia prostat >>

(Roerborn, 2004; Kramer, 2007; Rosette, 2006). Roehrborn CG, Schwinn DA. 2004. Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. J Urol;171(3):1029–35. Kramer G, Mitteregger D, et al. 2007. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol ;51(5): 1202– 16. Rosette, J. de la. , G. Alivizatos, S. Madersbacher, C. Rioja Sanz, et al. 2006. Guideline Prostatic Hyperplasia: European Association of Urology.